In vitro screening platform:
●Protein
-Radiopharmaceutical affinity study
●Cell
-Radiopharmaceutical cellular uptake and internalization study
-Radiopharmaceutical affinity and target specificity study
-Study of tumor cell killing by radiopharmaceuticals
In vivo efficacy platform:
●In vivo efficacy study of radiopharmaceuticals
in vitro screening platform:
●protein level
-Heat Drug Affinity Study
●cell level
-heat drugs
-heat drug
-hot drugs
in vivo pharmacodynamic platform:
●hot drugs in vivo
In vitro pharmacogenetic screening platform:
●Metabolic stability study of radiopharmaceuticals
In vivo pharmacogenetic screening platform:
●Radiopharmaceutical pharmacokinetics study (rats/mice, dogs, pigs, monkeys)
●Tissue distribution study and internal radiation exposure estimation
●Radiopharmaceutical excretion study (rats/mice)
●Radiopharmaceutical biodistribution study on tumor-bearing mice
●Radiopharmaceutical SPECT/PET/CT imaging study
Toxicological screening platform:
●Single-dose toxicity study of radiopharmaceuticals (rats/mice, dogs, pigs, monkeys)
●Multiple-dose toxicity study of radiopharmaceuticals (rats/mice, dogs, pigs, monkeys)
●In vitro hemolysis study of radiopharmaceuticals (laboratory rabbits)
●Vascular/muscular stimulation study of radiopharmaceuticals (laboratory rabbits)
●Allergenicity study of radiopharmaceuticals (guinea pigs)
●Constructed with reference to GLP standards
●Types of animal experiments: drug molecular screening, drug efficacy study, pharmacokinetic/toxicokinetic study, safety evaluation
●Laboratory animals: mice, rats, guinea pigs, rabbits, dogs, pigs, monkeys
●Qualified for the manipulation of nuclides F-18, Ga-68, Cu-64, I-124, I-123, Tc-99m ,Lu-177, I-131, Y-90, Ra-223, Ac-225, Th-227, etc.
Drug efficacy, pharmacokinetics and safety evaluation research center of 2,800 ㎡
Laboratory animals available for C-Ray
Laboratory mice/rats
Main applications: Pre-clinical chemical screening studies and IND safety evaluations, such as anti-tumor drug efficacy studies, pharmacokinetic and imaging studies, pharmacological safety trials, single-/multiple-dose toxicity trials, etc.
Guinea pigs
Main applications: Drug safety evaluation studies, such as systemic active allergy tests, passive skin allergy tests, etc.
Laboratory rabbits
Main applications: Drug safety evaluation studies, such as in vitro hemolysis tests, vascular/muscular stimulation tests, etc.
Beagle dogs
Main applications: Pre-clinical chemical screening studies and IND safety evaluations, such as pharmacokinetic studies, toxic dosage explorations, pharmacological safety trials, single-/multiple-dose toxicity trials, etc.
Laboratory pigs
Main applications: Pre-clinical chemical screening studies and IND safety evaluations, such as pharmacokinetic studies, toxic dosage explorations, pharmacological safety trials, single-/multiple-dose toxicity trials, etc.
Laboratory monkeys
Main applications: Pre-clinical chemical screening studies and IND safety evaluations, such as anti-tumor drug efficacy studies, pharmacokinetic studies, toxic dosage explorations, pharmacological safety trials, single-/multiple-dose toxicity trials, etc.
Service Cases
C-Ray has independently developed an automated Cu-64 purification and concentration system that realizes and guarantees stable multi-batch manufacturing of Cu-64 with the quality up to IAEA standards and a batch capacity of over 2Ci.
In vitro Cu-64 radioligand-receptor binding
Specific Cu-64 ligand-receptor binding with a nanomolar-level cellular affinity with receptor
In vivo efficacy study of Lu-177 therapeutic drug
In vivo efficacy study on mice bearing xenotransplanted tumor models, where the peptides or small molecules marked by Lu-177 presented good tumor inhibition effect