C-Ray-Pre-clinical Evaluation

Pre-clinical Evaluation

Home ꄲ Radiopharmaceuticals One-stop Service ꄲ Pre-clinical Evaluation

넳 넲

Provide pre-clinical pharmacological and toxicological evaluation for radiopharmaceuticals to identify advantageous molecules

Provide pre-clinical pharmacological and toxicological studies to support IND and NDA registration

Efficacy Evaluation

Pharmacokinetic Evaluation

Toxicological Evaluation

●Constructed with reference to GLP standards

●Types of animal experiments: drug molecular screening, drug efficacy study, pharmacokinetic/toxicokinetic study, safety evaluation

●Laboratory animals: mice, rats, guinea pigs, rabbits, dogs, pigs, monkeys

●Qualified for the manipulation of nuclides F-18, Ga-68, Cu-64, I-124, I-123, Tc-99m ,Lu-177, I-131, Y-90, Ra-223, Ac-225, Th-227, etc.

Drug efficacy, pharmacokinetics and safety evaluation research center of 2,800 ㎡

Laboratory animals available for C-Ray

Laboratory mice/rats

Main applications: Pre-clinical chemical screening studies and IND safety evaluations, such as anti-tumor drug efficacy studies, pharmacokinetic and imaging studies, pharmacological safety trials, single-/multiple-dose toxicity trials, etc.

Guinea pigs

Main applications: Drug safety evaluation studies, such as systemic active allergy tests, passive skin allergy tests, etc.

Laboratory rabbits

Main applications: Drug safety evaluation studies, such as in vitro hemolysis tests, vascular/muscular stimulation tests, etc.

Beagle dogs

Main applications: Pre-clinical chemical screening studies and IND safety evaluations, such as pharmacokinetic studies, toxic dosage explorations, pharmacological safety trials, single-/multiple-dose toxicity trials, etc.

Laboratory pigs

Main applications: Pre-clinical chemical screening studies and IND safety evaluations, such as pharmacokinetic studies, toxic dosage explorations, pharmacological safety trials, single-/multiple-dose toxicity trials, etc.

Laboratory monkeys

Main applications: Pre-clinical chemical screening studies and IND safety evaluations, such as anti-tumor drug efficacy studies, pharmacokinetic studies, toxic dosage explorations, pharmacological safety trials, single-/multiple-dose toxicity trials, etc.

Service Cases

C-Ray has independently developed an automated Cu-64 purification and concentration system that realizes and guarantees stable multi-batch manufacturing of Cu-64 with the quality up to IAEA standards and a batch capacity of over 2Ci.

In vitro Cu-64 radioligand-receptor binding

Specific Cu-64 ligand-receptor binding with a nanomolar-level cellular affinity with receptor

Cellular uptake and internalization of Cu-64 radiolabeled ligand

Saturation binding test of Cu-64 radiolabeled ligands

In vitro Lu-177 radioligand-receptor binding

Specific Lu-177 ligand-receptor binding with a nanomolar-level cellular affinity with receptor

Cellular uptake and internalization of Lu-177 ligands

Saturation binding test of Lu-177 ligands

In vitro Ac-225 radioligand-receptor binding

3 groups of specific Ac-225 ligand-receptor binding with a nanomolar-level cellular affinity with receptor

Cellular uptake and internalization of Ac-225 ligands

Saturation binding test of Ac-225 ligands

In vivo efficacy study of Lu-177 therapeutic drug

In vivo efficacy study on mice bearing xenotransplanted tumor models, where the peptides or small molecules marked by Lu-177 presented good tumor inhibition effect

In vivo efficacy of Lu-177-marked peptides

In vivo efficacy of Lu-177-marked small molecules

In vivo efficacy study of Ac-225 therapeutic drug

In vivo efficacy study on mice bearing xenotransplanted tumor models, where the peptides or antibodies marked by Ac-225 presented good tumor inhibition effect

In vivo efficacy of Ac-225-marked peptides

In vivo efficacy of Ac-225-marked antibodies